Търсил съм много по медицинските сайтове и нищо убедително не съм открил. Ако имате написано нещо сериозно по въпроса, което може да ме убеди - ще се радвам да го прочета!
При рака на белия дроб сигурно се увеличава креатина, но едва ли увеличения креатин предизвиква рак на белия дроб? Сигурно е възможно да подпомага метастазирането на вече образувани ракови клетки, но едва ли самия креатин предизвиква трансформацията. Иначе ако някой пушач вземе да пие и креатин - да е развил рак на белия дроб моментално.
Я да ви питам аз друго:
Какво значи чаена лъжичка? Средно пълна или с връх? Или пък нещо друго?
А за приема, нали се препоръчва да се пие с напитка съдържаща повечко въглехидрати. Та, няма как да давам толкова пари за сок, а компотите в мазата са на привършване :) Та става ли да бучна две лъжици захар във водата например?
[quote author=“Achille”]Я да ви питам аз друго:
Какво значи чаена лъжичка? Средно пълна или с връх? Или пък нещо друго?
А за приема, нали се препоръчва да се пие с напитка съдържаща повечко въглехидрати. Та, няма как да давам толкова пари за сок, а компотите в мазата са на привършване :) Та става ли да бучна две лъжици захар във водата например?
Няма да постигнеш добър ефект. Захарта (захарозата) няма ефективността на монозахаридите като глюкоза и фруктоза. Вземи си глюкозен разтвор или още по-добре - глюкоза на прах от аптеката и пий креатина с 10-15г глюкоза (ако е на прах).
Относно лъжицата - който взима креатина с чаена лъжичка никога не знае точно колко взима. Аз си измерих дозата в една малка бехерова чашка на електронната везна в лабораторията и си теглих една чертичка с перманентен маркер докъдето трябва да се напълни - така е малко по-точно от с лъжицата, а най-сигурно е винаги да си го мериш на везната.
мисля да почна да зимам креатин по тази схема: 5 гр преди тренировка и 5гр след.кажете кво мислите/
//offtopic: Хей модераторите, какво правите с темите за креатина? Триете ли ги? Не може да е истина някой пак да пита за схема на приемане на креатина... :lol:
Абе незнам аз си го фукам и не ми дреме дано нямам проблеми пийте по 5 преди и след и да ви боли фара мисля че си е екстра не му мислете толкова и не се вживявайте по важно е колко си як отколкото как изглеждаш макар че и как изглеждаш е важно затова работете върхо двете УСПЕХ НА ВСИчКИ !!!
Пишетена кирилица. Мнението ви беше механично преведено. Да не се повтаря!
Mr_Muskul
23.01.05
20:08
#49
Интересно ми е креатина има ли някакво действие върху сърцето ?
не знам какво му е действието върху сърцето , но определено като го пиех имах леки болки.но това беше 2-3 пъти
Аз не съм забелязал никакви проблеми още повече пък върху сърцето но всеки е различен но точно върху сърцето не съм и чувал
Сърдечния мускул се дехидратира при прием на креатин. Това е единствения риск за сърцето от страна на креатина, респективно опасност от инфаркт. По тази причина креатин не се препоръчва да се пие при изтощителни (кардио) тренировки. Креатина е за силови тренировки, а не за кардио. Използвайте всичко по предназначение, а не безразборно!
perlsite, според мен можеш да се дехидратираш ако не консумираш достатъчно вода, но иначе знам че креатина се използва не само от бодибилъдърите. Дефакто след олимпиадата в Барселона, на който е “официалното” бойно кръщение на креатина, креатин се приема от всички спортисти, някъде пишеше че 80-90% от олимпийските шампиони суплементират с креатин., същото важи примерно за НХЛ и т.н.
Моля те ако имаш по-сериозни аргументи за евентуален сърдечен риск при прием на креатин и активни кардио занимания да ги споделиш, за да не останат нещата недоизказани.
06.02.05
17:39
#54
По-долу ще ви пусна две много хубави статии за креатина но са на английски и са писани около 1997 година от един от водещите хранителни експерти в света.
What I am about to tell you is not going to make me a very popular person with many supplement manufacturers. In fact, some of them are going to be down right pissed off at me. On the other hand, some of them are going to be happy someone spilled the beans and told the truth. Finally, some of them will be totally unaware of this information and will be shocked when they read it. Basically, I fully expect this article to cause a sh*% storm that will reverberate throughout the supplement industry. The only people who I know are going to be happy about this article is the consumer, but I am getting ahead of myself. As we all know, creatine is one of the best bodybuilding supplements ever discovered. It increases strength, lean body mass, and, to a lesser extent, endurance. If that were not enough, it’s relatively cheap to boot! What more could we ask for from a supplement? When creatine was first introduced it was sort of pricey, but no one really cared because it worked so well. As time went on and more companies began selling creatine, the inevitable price war began and prices came down. At that point creatine was only being produced by a few companies, so creatine was basically creatine and the price was the only real consideration. As is typical of the market place, once creatine became big business, several new manufacturers popped up and it became no longer a price war as much as a quality war. The expression “creatine is creatine” no longer holds true. More on that shortly.
At this time there are probably four-five companies large enough to mass produce creatine for the sports nutrition market. These companies in turn sell their product in huge bulk amounts to various distributors around the world. As far as the mass producers are concerned, there is a large German company, two companies out of China, and two in the United States. Though there are various other companies, for this article we will basically concern ourselves with these five major producers which probably comprise 80-90% of the creatine production market.
Why I had to write this article
The supplement industry in the United States is by and large a self-regulated industry. Unlike other countries, we (the USA) don’t have government constantly telling us what we can and cannot do with our supplements. Though they have been trying to discredit supplements for decades, the FDA and pharmaceutical/ medical industrial complex have largely failed to do so. As a self-regulated industry, we must do just that. Let me state here and now, I am all for self-regulation and totally against government regulation when it comes to supplements. When we find gross problems, we have to expose them no matter what the cost. Any supplement that is found to be potentially dangerous, terribly misleading, or otherwise a total scam, must be exposed as such. If we don’t do it, then we allow the “powers that be” (who have an interest in discrediting the supplement industry) to get one step closer to the Orwellian scenario of other countries. I thought long and hard as to whether or not I should write this article, but in the end, as a person of good conscience and ethics, I knew I had to. In the end, it will cost the entire supplement industry far more than any one loss could ever cost a single company if problems with a certain product are not exposed. As far as I am concerned, this is us airing out or own dirty inter-industry laundry and policing our own, instead of waiting for the “don’t confuse us with the facts” popular media or other groups to come after the supplement industry. I know it must sound like I am almost apologizing for writing this article, and in a way I am. It could potentially cost certain people a great deal of money. On the other hand, it could also make some other person a great deal of money, depending on where they fall (this will make more sense to the reader as you read along). In the end, the truth can never been denied, it can only be delayed. With each day of delay, the cost to everyone goes up. Nuff said.
Are you getting more than you paid for?
Most of us are always happy when we get more than we paid for, but in some instances, it’s not such a good idea. If we are buying say vitamin C and the label says “500mg per capsule” and laboratory analysis reveals it contains 600mg, then that is a great thing. However, if we test a product and not only does it contain what the label claims, but several other compounds we did not know were in there and had no place being in there, then that’s a completely different story. For example, when the amino acid L-Tryptophan was taken off the market for the death of several people, it was not because of the L-Tryptophan itself, but because of a chemical contaminant found in a batch of the L-tryptophan that was not supposed to be there. This was a perfect example of getting more than you paid for in the worst possible scenario. What I am going to write about in this article certainly is not as bad as the L-tryptophan fiasco, but it could be a potential health concern.
So after that long, cryptic, and bizarre introduction, what am I getting at? Recently, a company tested the five largest creatine manufacturers products and tested the products of various distributors from the USA, Germany, Great Britain, and other countries. At this time, the company who did the testing wishes to remain anonymous, lest they be accused of throwing stones at the supplement industry. However, this is a very large and reputable company and they stand behind their test results. Also, I know this company to be one of the worlds most reputable companies, so I had no problems with their testing results or methods. The test results came to me through the back door so to speak. So what was tested for and what did it reveal? The creatine products were tested for: Dicyandiamide, Creatinine, Dihydrotriazine, and sodium content. What did the tests reveal? It revealed that there is a wide range of differences between creatine products from different manufacturers. The purity level of all the creatine products were also tested and they generally fell between 88 and 92%. Now before you go off yelling “but my creatine says 99% pure creatine monohydrate on the bottle,” you have to remember there is a small amount of water in creatine monohydrate. Before we bother with the results, we need to take a look at the chemicals that were tested for-and subsequently found- in these samples. What really bothered me was the fact that there is little safety research on some of these chemicals, most notably the dihydrotriazine. I did Med-line searches, looked through various chemical data related books (i.e. the Merck Index and other publications), made many phone calls to chemists, spent hours on the internet, and was amazed to find so little real safety data on some of these materials. Considering the fact that some creatine products contain fairly high amounts of these chemicals, the lack of solid safety data did not make me feel very comfortable. The major point of this is really the amount of creatine ingested in relation to the amount of contaminant present. It’s not that a compound has a small amount of some contaminant per se, but the levels of the contaminant is found in relation to how much of the product is consumed is the real question. In the December issue of Health and Nutrition Breakthroughs (p12, 1997) Dr. Podell addressed the same concern regarding creatine as I have when he stated “...there is the potentially important issue of product purity. Given the high doses of creatine most people take, even a minute toxic impurity could have a dangerous effect. Unfortunately we cannot be sure of a manufacturers’ quality controls.”
As we all know, people don’t just take 500mg (1/2 a gram) of creatine, they take 10,000mg (10g), 20,000mg (20g), or even 30,000mg (30g) of creatine per day, so even a small amount of a contaminant (such as the dihydrotriazine) can add up quickly. For example, one creatine product contained as much as 18,000 parts per million (PPM) of Dicyandiamide. If a person is taking in ten grams per day of creatine, that’s 180 mg of this chemical a day. If you are taking in 30g a day of creatine-as is often the case during the loading phase-you would be getting a whopping 540mg a day of dicyandiamide!
The Chemicals
Dicyandiamide (DC): DC is actually a derivative of one of the starting chemicals (cyanamide) used in creatine production. DC is formed during the production of creatine products, and large amounts found in a product are considered the result of an incomplete or inefficient process. A quality creatine product will contain very small amounts, less than 20-50ppm. At this time, DC does not appear to be a particularly toxic chemical. Oral studies with animals (rats and dogs) lasting up to 90 days have not shown serious toxicity or carcinogenic effects, and acute poisoning also takes very high amounts. DC appears to have many uses in the chemical industry. Some of the more interesting is the use of DC in the production of fertilizers, explosives, fire proofing compounds, cleaning compounds, soldering compounds, stabilizer in detergents, modifier for starch products, and a catalyst for epoxy resins. At the concentrations found in some of the creatine products (see below), it’s a good thing this stuff does not appear to be particularly toxic. However, as far as I am concerned, I don’t want to be eating the stuff. One interesting point as it relates to DC and toxicity is, if one looks at the safety sheet on the stuff it states that DC breaks down into hydrogen cyanide gas when exposed to a strong acid. Hydrogen cyanide gas is very toxic and has been used as a chemical warfare agent! As Bruce Kneller points out (see side bar), stomach acid, which has a PH of 2, is a very strong acid. Is even a tiny amount of hydrogen cyanide gas produced from the intake of large amounts of DC? The chemist I spoke to did not seem to think so and the safety data with animals would tend to support this, but who knows. Bruce might be overreacting a bit on this, but it’s better to lean on the cautious side with such things. Bottom line, it’s best not to be eating large amounts of DC in this writer’s opinion.
Dihydrotriazine (DT): DT appears to be the real mystery chemical as far as potentially toxic contaminants found in some creatine products. One company had it listed as “...Dihydrotriazine is often found in various creatine products. This substance is a byproduct of non-optimized creatine productions and consequently widely spread over creatine products. Dihydrotriazine is a compound with unknown pharmaceutical and toxicological properties.” It was virtually impossible to find any useful safety data on this chemical. However, DT is part of a large family of chemicals known as the “triazines.” It is an organic base with many derivatives. Some of these derivatives are toxic while others are known to be non-toxic, so it is very difficult to come to any real solid opinion regarding the potential toxicity of this chemical. One chemist I spoke to from a major pharmaceutical supply company said to me on the phone “it’s safe to say that there will be major differences in toxicity between derivatives since ‘triazine’ simply means possessing three C=N-H groups. Some derivatives are highly toxic.” Bill Roberts, a medicinal Chemist and writer for Dan Duchaine’s Dirty Dieting news letter commented after I sent him over this information: “There really is no way to say just how high a chronic intake of this chemical [these chemicals] is safe in humans from the information given. If the amounts were very small, say a few milligrams per week, it’s a reasonable guess that there would probably be no problem. But if a creatine brand has say 1% of this impurity [these impurities] then people are going to be consuming thousands of milligrams of this compound [these compounds] over time. I think we have to be concerned about taking so much of something that really isn’t well studied in humans for safety. It would certainly be unwise to assume thattoxicity is not an issue. If the consumer has a choice between a creatine brand that contains this impurity [these impurities] in significant amounts, and one that is more pure, I’d certainly recommend spending the extra money and obtaining the purer product.”
So as you can see, we are left with a major question mark regarding DT. For me, the less I know about a chemical the less of it I want to find in any product I am ingesting. Though this chemical might turn out to be perfectly harmless, I think it should not be found in any amount and thus should be non-detectable (n.d.) in the ppm range until we know more about this chemical. As you can see from the tests, some companies have n.d. amounts while others have far more than that. I find this unacceptable, and so should you.
Creatinine: Creatinine is one of the easy compounds to discuss on this list. Creatinine is actually a natural byproduct of creatine metabolism in the human body and of creatine production. A small amount can be found in every creatine product. However, in some products large amounts can be found, as high as 7700 ppm in one case (see chart). It is probably safe to say that the ingestion of creatinine is a safe endeavor. There is some research that links the ingestion of creatinine from meats with increased colon cancer incidence, but in all honesty I would not put much stock in that or get all worked up about it . The point is, when I buy creatine I want to eat creatine, not creatinine. Though a natural byproduct of creatine metabolism, it does not have any ergogenic effects and therefore I don’t want large amounts of it in my creatine, period. A high quality creatine product should contain less than 100ppm of creatinine in my opinion.
Sodium: Like the aforementioned creatinine, sodium is an easy one to talk about. Also, like creatinine, it is a generally safe thing to ingest at normal intakes. At the levels found in these creatine products, the amount of sodium added to the diet is very small and should pose no problems, even to the most sodium phobic person. However, like I said before, when I pay for creatine I want creatine, not sodium. The lowest sodium content was 20ppm and the highest was 500ppm. I leave it to the reader to decide what is a tolerable sodium content to them.
Conclusion
Believe it or not, the company who did the testing told me that although those were the main chemicals they tested for, some creatine products read like a who’s who of different chemical compounds, though they admitted that they are usually found in trace amounts. As for the consumer, if it were me, I would demand the HPLC test results from whom ever I was buying my creatine from regarding the chemicals listed in this article. If you don’t care, that’s OK also. As for me, I will make sure my creatine comes only from companies and distributors who sell creatine made by the large German company, or other companies, who clearly have their collective act together when it comes to producing an ultra pure creatine product. Bottom line? The expression “creatine is creatine” no longer holds true. However, a high quality creatine product it still the best thing going in bodybuilding/sports supplements.
Dicyandiamide Creatinine Dyhydrotriazine Sodium
German producer < 20 ppm < 50 ppm n.d. 20 ppm
Chinese producer #1 18000ppm 100ppm n.d. n.d.
Chinese producer #2 2300ppm 1500ppm n.d. n.d.
USA producer #1 300ppm 2500ppm 90ppm 500ppm
USA producer #2 400ppm 190ppm 410ppm 295ppm
USA distributor #1 120ppm 220ppm 60ppm 493ppm
USA Distributor #2 80ppm 1480ppm 30ppm n.d.
USA Distributor #3 250ppm 400ppm 80ppm n.d.
USA Distributor #4 30ppm 70ppm 300ppm n.d.
USA Distributor #5 n.d. 200ppm n.d. n.d.
USA Distributor #6 40ppm 800ppm 180ppm n.d.
USA Distributor #7 30ppm 400ppm 120ppm n.d.
USA Distributor #8 120ppm 350ppm 20ppm 478ppm
USA Distributor #9 30ppm 90ppm n.d. n.d.
USA Distributor #10 30ppm 100ppm n.d. n.d.
GB Distributor #1 < 20ppm 80ppm 30ppm n.d.
GB Distributor #2 80ppm 210ppm 160ppm n.d.
GB Distributor #3 < 20ppm 90ppm n.d. n.d.
GB Distributor #4 2600ppm 100ppm n.d. n.d.
GB Distributor #5 4700ppm 7700ppm 60ppm n.d.
GB Distributor #6 60ppm 320ppm 60ppm n.d.
GB Distributor #7 7700ppm 2900ppm 120ppm n.d.
GB Distributor #8 20ppm 80ppm n.d. n.d.
GB Distributor #9 20ppm 100ppm n.d. n.d.
GB Distributor #10 9000ppm < 50ppm 40ppm n.d.
GB Distributor #11 600ppm < 50ppm 20ppm n.d.
German Distributor 50ppm 100ppm n.d. n.d.
Spanish Distributor 30ppm 200ppm n.d. n.d.
Интересно е да се направи сравнение с тогава и сега.Колко ли неща са се променили?
06.02.05
17:43
#55
WHAT’S IN YOUR CREATINE?-беше заглавието на първа част.Ето и втора част писана през 1999 година.
As some well informed readers might recall, I wrote an expose on the various impurities and contaminants found in certain creatines on the market almost a year ago. The article was called “What’s really in your creatine?”. The article took a close look at the large variations in the quality of different creatines and killed the long standing myth that “creatine is creatine.” I expected the article to have an effect on the creatine market both from a wholesale and a retail perspective, and it did. As I predicted in that article, It also got me into hot water with many companies and individuals who sell less than pure high quality creatine. My exact words were “What I am about to tell you is not going to make me a very popular person with many supplement manufacturers. In fact, some of them are going to be down right pissed off at me.” I recall the drunk owner of one well known supplement company coming up to me at an after hours party at a convention and slurring “Hey Brink, you cost me a lot of money with that article of yours” to which I responded “serves you right for selling low grade creatine!” I knew where he got his creatine and it was junk. The article examined several key impurities often found in low grade creatines such as Dicyandiamide, Creatinine, Dihydrotriazine, and Sodium. From the tests that were conducted on a dozen or so brands of creatine using high-performance liquid chromatography (HPLC), it appeared the creatine made by a large pharmaceutical company out of Germany was far and away superior to creatine manufactured elsewhere, particularly China where the above chemicals could be found at very high levels.
For what ever reason, I have gotten the unenviable reputation as some sort of defender of the of the sports supplement consumer. A few months ago I came into the possession of a whole new batch of tests on creatine, various liquid creatines, and pyruvate products, from the same lab that did the original tests on creatine. The results came to me through the back door so to speak but the company who did the tests is a multi billion dollar pharmaceutical company and one of the largest producers of chemical intermediates (including the chemicals used to make creatine) in the world.
They know their stuff when it comes to testing for chemical impurities, not that it takes a multi billion dollar pharmaceutical company to do such tests anyway. I sat on the test info for a few months seriously considering whether I really wanted to write another such article and deal with the next drunk guy at some convention who gets mad at me because I exposed the fact that he sold low grade creatine. Hey, it’s not my fault what people do to save a few bucks rather than shoot for the good stuff like an honest business person should. I know the words “sports nutrition” and “honesty” seem like an oxymoron, but there are a few good people and good companies out there, not to mention the fact that a quality creatine really is one of the best supplements going and is perfectly safe as many studies have shown. In the end, I decided I could not sit on this information and live with myself. So, I dug through the giant pile of papers on my desk, blew the dust off the test results, and sat down to write another article on the current state of some of the creatine supplements we stick in our mouth. You ain’t gonna like what you read unfortunately.
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The Current State of Creatine
In some ways, the current state of creatine is pretty much the same as it was last year. A few -though growing number- of companies willing to sell the more expensive and purer creatine and the rest selling creatines that range from OK to really bad! In some respects, at least from these tests, it appears that several of the US manufacturers have improved while the Chinese manufacturers have gotten worse! The accompanying chart is a whole new batch of tests from that of last years tests and shows some creatines are loaded with impurities, in some cases up to 34,000 parts per million (ppm) of a single impurity which is almost 3.5% of the product! Now remember, people don’t take say 200 milligrams of creatine, they take 5,000 or even 10,000 milligrams (5-10 grams) of creatine at a time. So, if the product has as much as 3.4% of an impurity, that’s 340mg of the impurity per 10 gram serving. During the loading faze the number would be even higher! It’s just a good thing that these chemical impurities don’t appear to be toxic though one of them (dihydrotriazine) has no toxicity data and therefore should always be found in the non-detectable (n.d.) range in my opinion. A high quality creatine will contain 50ppm or less of dicyandiamide, 100ppm or less of creatinine, 100ppm or less of sodium, and non-detectable (n.d.) amounts of dihydrotriazine. The “good stuff ” easily meets these standards and the rest often fall well short as the chart clearly shows. Now of course there are always going to be some batch to batch variations in the above numbers for any manufacturer, but those figures would be the average for any good creatine.
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HPLC Creatine Test Results
Creatinine Dicyandiamide Dihydrotriazine Sodium
1 German Manufacturer < 50 ppm < 20 ppm n.d. trace
2 US Manufacturer #1 190ppm 400ppm 410ppm 750ppm
3 US Manufacturer #2 300ppm 100ppm 40ppm no data
4 US Manufacturer #3 2500ppm 300ppm 90ppm no data
5 Chinese Manufacturer #1 1500ppm 2300ppm n.d. no data
6 Chinese Manufacturer #2 100ppm 18000ppm n.d. no data
7 US Distributor #1 50ppm 20ppm n.d. trace
8 US Distributor #2 520ppm 40ppm 24ppm 280ppm
9 US Distributor #3 220ppm 120ppm 60 ppm 1250ppm
10 US Distributor #4 3000ppm 2000ppm 16ppm 220ppm
11 US Distributor #5 320ppm 60ppm 60ppm no data
12 US Distributor #6 50ppm 34000ppm! 72ppm 530ppm
13 US Distributor #7 70ppm 30ppm 300ppm no data
14 US Distributor #8 210ppm 80ppm 160ppm no data
15 US Distributor #9 50ppm 20ppm n.d. trace
16 US Distributor #10 180ppm 80ppm 176ppm 360ppm
17 US Distributor #11 1480ppm 80ppm 30ppm no data
18 US Distributor #12 50ppm 20ppm n.d. no data
19 GB Distributor #1 60ppm 1500ppm n.d. no data
20 GB Distributor #2 50ppm 20ppm n.d. trace
21 GB Distributor #3 80ppm 20ppm n.d. no data
22 Spanish Distributor 200ppm 30ppm n.d. no data
23 Canadian Distributor 50ppm 20ppm n.d. trace
n.d. = non-detectable
HPLC = high-performance liquid chromatography
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The State of Liquid Creatines and Gels
Where do I begin with the liquid creatine issue? As you can see from the testing chart done on liquid creatine and gels, it was not a very large sample size. However, the tests were done on the better known brands of liquid creatine and gels. What if a larger sample size of liquid and gel products had been tested? I would expect to see pretty much the same results. Why? Well, even though every company selling liquid creatines and gels wants you to believe they are the one company who has discovered the magic chemical formula for keeping creatine stable in any type of liquid/gel, there is no reason at this time to believe it’s true. What I do know is some of the top R&D scientists in the world have told me repeatedly that creatine will not and does not stay stable over months or years in a liquid or a gel period. I was told point blank by one of the largest creatine manufacturers in the world that they had been asked by one of the largest sports drink manufacturers in the world to design a liquid sports drink with creatine in it. They were unable to find a way to make the creatine stable in liquid no matter what they tried and lost millions in potential sales by being unable to produce the product. I suppose it’s possible that some small company or entrepreneur has discovered a stabilization process that eluded one of the top laboratories in the world that works with creatine, but I highly doubt it. Now, I actually have to back up somewhat from those harsh statements about liquid creatines and gels. I was recently contacted by a scientist from a company who said they are 90% sure they will have truly stabilized liquid creatine to be launched in the near future but none of them felt anything currently on the market was stable. Our small test results would seem to agree with that assessment, but anything is possible right? As the reader can see, one gel was as low as 11.2% creatine with lots of creatinine and the liquid was only 14.4% creatine. I leave it to the reader to make up their own mind regarding such products.
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HPLC Creatine Test Results (Gels and Liquids)
%Creatine Creatinine Dicyandiamide Dihydrotriazine Sodium
1 Gel #1 14.4 5000 ppm 120 ppm n.d. 840 ppm
2 Gel #2 11.2 7000 ppm 54 ppm n.d. no data
3 Liquid 16.8 5000 ppm 570 ppm 860 ppm no data
n.d. = non-detectable
HPLC = high-performance liquid chromatography
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Conclusion
So what can the reader do with this information? As I stated in the first article: “As for the consumer, if it were me, I would demand the HPLC test results from whom ever I was buying my creatine from regarding the chemicals listed in this article.” The same still holds true today and the tests should of course be done by an independent lab. Most companies when asked for test results on creatine will send you a simple purity test.
A purity test will tell you little to nothing. The purity level of all the creatine products were also tested and they generally fell between 88 and 92%. Now before you go off yelling “but my creatine says 99% pure creatine monohydrate on the bottle,” you have to remember there is a small amount of water in creatine monohydrate which leaves plenty of space to hide impurities. So, if these impurities concern you, you should ask for the HPLC tests on those specific impurities. If you don’t care about it hey, that’s your business. So, more today than ever, the old expression “creatine is creatine” fails to hold water. However, a high quality creatine product it still the hottest thing going in bodybuilding/sports supplements. It increases strength, lean body mass, and, to a lesser extent, endurance, so a high quality brand of creatine is still a safe and effective supplement.
The astute reader will recall, I also mentioned I had the testing results for many pyruvate products in the beginning of the article. If you think some of the creatines are bad, wait until you see what’s in your pyruvate products! That’s for another article. Keep an eye out for it!
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A brief description of the impurities found in low grade creatines
Dicyandiamide (DC): DC is actually a derivative of one of the starting chemicals (cyanamide) used in creatine production. DC is formed during the production of creatine products, and large amounts found in a product are considered the result of an incomplete or inefficient process. A quality creatine product will contain very small amounts, less than 20-50ppm. DC does not appear to be a particularly toxic chemical. Oral studies with animals (rats and dogs) lasting up to 90 days have not shown serious toxicity or carcinogenic effects, and acute poisoning also takes very high amounts (LD50 /oral / rats = <5000mg/kg). DC appears to have many uses in the chemical industry. Some of the more interesting is the use of DC in the production of fertilizers, explosives, fire proofing compounds, cleaning compounds, soldering compounds, stabilizer in detergents, modifier for starch products, and a catalyst for epoxy resins (AllChem Industries data sheet. AllChem Industries inc., Gainesville FL, 32607.). At the concentrations found in some of the creatine products (see below), it’s a good thing this stuff does not appear to be particularly toxic. However, as far as I am concerned, I don’t want to be eating the stuff.
Creatinine: Creatinine is one of the easy compounds to discuss on this list. Creatinine is actually a natural byproduct of creatine metabolism in the human body and of creatine production. A small amount can be found in every creatine product. However, in some products large amounts can be found (see chart). It is probably safe to say that the ingestion of creatinine is a safe endeavor. There is some research that links the ingestion of creatinine from meats with increased colon cancer incidence, but in all honesty I would not put much stock in that or get all worked up about it . The point is, when I buy creatine I want to eat creatine, not creatinine. Though a natural byproduct of creatine metabolism, it does not have any ergogenic effects and therefore I don’t want large amounts of it in my creatine, period. A high quality creatine product should contain less than 100ppm of creatinine in my opinion.
Sodium: Like the aforementioned creatinine, sodium is an easy one to talk about. Also, like creatinine, it is a generally safe thing to ingest at normal intakes. At the levels found in these creatine products, the amount of sodium added to the diet is very small and should pose no problems, even to the most sodium phobic person. However, like I said before, when I pay for creatine I want creatine, not sodium.
Dihydrotriazine (DT): DT appears to be the real mystery chemical as far as potentially toxic contaminants found in some creatine products. One company had it listed as “...Dihydrotriazine is often found in various creatine products. This substance is a byproduct of non-optimized creatine productions and consequently widely spread over creatine products.
Dihydrotriazine is a compound with unknown pharmaceutical and toxicological properties.” It was virtually impossible to find any useful safety data on this chemical. However, DT is part of a large family of chemicals known as the “triazines.” It is an organic base with many derivatives. Some of these derivatives are toxic while others are known to be non-toxic, so it is very difficult to come to any real solid opinion regarding the potential toxicity of this chemical. One chemist I spoke to from a major pharmaceutical supply company said to me on the phone “it’s safe to say that there will be major differences in toxicity between derivatives since ‘triazine’ simply means possessing three C=N-H groups. Some derivatives are highly toxic.” Bill Roberts, a regular contributor to Mesomorphosis and former writer for Dan Duchaine’s Dirty Dieting newsletter commented after I sent him over this information: “There really is no way to say just how high a chronic intake of this chemical [these chemicals] is safe in humans from the information given. If the amounts were very small, say a few milligrams per week, it’s a reasonable guess that there would probably be no problem. But if a creatine brand has say 1% of this impurity [these impurities] then people are going to be consuming thousands of milligrams of this compound [these compounds] over time. I think we have to be concerned about taking so much of something that really isn’t well studied in humans for safety. It would certainly be unwise to assume that toxicity is not an issue. If the consumer has a choice between a creatine brand that contains this impurity [these impurities] in significant amounts, and one that is more pure, I’d certainly recommend spending the extra money and obtaining the purer product.”
So as you can see, we are left with a major question mark regarding DT. For me, the less I know about a chemical the less of it I want to find in any product I am ingesting. Though this chemical might turn out to be perfectly harmless, I think it should not be found in any amount and thus should be non-detectable (n.d.) in the ppm range until we know more about this chemical. As you can see from the tests, some companies have n.d. amounts while others have far more than that. I find this unacceptable, and so should you.
[quote author=“Pars”]perlsite, според мен можеш да се дехидратираш ако не консумираш достатъчно вода, но иначе знам че креатина се използва не само от бодибилъдърите. Дефакто след олимпиадата в Барселона, на който е “официалното” бойно кръщение на креатина, креатин се приема от всички спортисти, някъде пишеше че 80-90% от олимпийските шампиони суплементират с креатин., същото важи примерно за НХЛ и т.н.
Моля те ако имаш по-сериозни аргументи за евентуален сърдечен риск при прием на креатин и активни кардио занимания да ги споделиш, за да не останат нещата недоизказани.
Гледах по ТВ едно филмче (за телата на елитните спортисти и по-специално за бегачите, които имат нужда от взривна сила), мисля, че беше на BBC. Обясняваха, точно как действа креатина върху сърцето и как сърдечния мускул се дехидратира за сметка на скелетните мускули. Поради което препоръчваха при тежки аеробни тренировки да се избягва приема на креатин или да се компенсира с голям прием на вода.
Същото би се получило ако правиш аеробна тренировка и не приемаш достатъчно вода, но ако консумираш и креатин риска от инфаркт се повишава значително. Горе-долу това си спомням от филма.. може би преди 1-2 години съм го гледал. Беше доста интересно направен със типичните 3D изгледи на сърцето и движението на кръвта и т.н.
Е да беше и на булгериан (статията) да мога да я разбера пък и другите щеше да е екстра
Според мен щом от МОК са разрешили креатина,няма страшно.Не ми
говорете за бизнес,щото и про-хормоните и ефедрина са бизнес,но ги спряха.Толкова.Над 20 грама креатин увредат сърцето.Ами изпий примерно 15 литра вода или изяж 4 кила месо и виж кво ще стане с теб.
Иван Абаджиев цитира Хипократ:
“Всичко е отрова,зависи от дозата”
Хех.. то МОК преди няколко години беше решен да забрани креатина, но след като се направиха някой проучвания се оказа, че 90% от спортистите го ползват... и ако бяха го добавили към забранените субстанции още на първото сериозно състезание щеше да се получи грандиозен скандал.. и поради тази причина МОК реши да остави въпроса отворен. Няма спор в МОК дали трябва да се забрани креатина, въпроса е кога е възмоно да стане това (в момента е просто невъзможно). Всъщност позицията на МОК е да се забранят всички субстанции които се приемат в неразумно (неестествено) големи дози, чиито прием е с цел да се даде приемущество на един спортист над друг. Сами се сещате, че по дефиниция креатина спада в тази категория.