Влошена лептинова чувствителност + изтощителни тренировки (кардио) = кратък живот

Един цитат от блога на д-р Джак Круз,  за това колко е лошо да се прави кардио когато нямате добра лептинова чувствителност. Проблемът е, че това изтощава запаса на тялото от стволови клетки и съответно намалява продължителността на живота и ни прави по-податливи към сърдечни удари, Алцхаймер, рак и др. Феновете на голямата мускулна маса също да се замислят, защото изграждането и поддържането на мускули и органи, които са по-големи от нормалното за скелетната структура, също изчерпва запаса на тялото от стволови клетки.

Заб: (LR = leptin resistant, LS = leptin sensitive)

Why should I avoid aerobic exercise during the reset?
This will require some explanation. If you’re LR, you are a sugar burner, not a fat burner. That means you can not do glycolytic exercise until your muscles and lever become completely LS as well. Your brain being LS is not enough. If your muscles are still LR, they can’t properly use the glucose or the fat delivered to them. This is detailed in the “Why is Oprah still Fat” post.

Another to avoid aerobic exercise at this stage is because the AMPk pathways are not working well yet. (This will be the focus of an upcoming blog post.) AMPk is stimulated by re-teaching your muscles and liver how to deplete glycogen and metabolically respond to hypoxia and cellular stressors. Any time metabolism is stressed, AMPk should respond in kind with big results. In LR, it does not work well at all. This is why body composition is trashed in LR states. If you do aerobic exercise when you are still leptin resistant, you send signals to the mitochondria that conditions are really bad. Instead of making new mitochondria to help out, you wind up killing your cells via apoptosis. New stems cells are recruited to replace the suicidal cells. Sounds good? The problem is those stem cells were going to help extend your life span, and, well, you just shortened it! This is why NFL players, bodybuilders, and marathoners don’t live long as group, and why they get many disease early, such as heart attacks, Alzheimers, and cancer. Not good. Longevity always mandates we protect our stem cells. We only want to use them when we really need them. If you use them early in life, you’re subtracting years from the end of your life.

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